Effectiveness and safety of atorvastatin in treatment of epidual effusion after cranioplasty performed

Abstract

Objective To investigate the effect of atorvastatin in the treatment of patients with epidual effusion after digital plastic titanium mesh cranioplasty. Methods A total of 58 patients with epidual effusion after digital plastic titanium mesh cranioplasty from August 2014 to January 2019 were randomly divided into control group (N = 23) and atorvastatin group (N = 35). Control group was given routine treatment, such as dilatation, improvement of microcirculation and nutritional nerve. Atorvastatin group was given atorvastatin therapy on the basis of routine treatment. The clinical efficacy of patients was evaluated after one month of treatment and the complete absorption time of epidual effusion in patients was recorded during the follow-up period from 2 to 4 months. Results The total effective rate of atorvastatin group was significantly higher than that of control group [91.43% (32/35) vs. 56.52% (13/23); Z = -3.143, P = 0.002]. Compare with control group, the total absorption time of epidual effusion in atorvastatin group was significantly shorter [(32.77 ± 7.00) d vs. (40.30 ± 13.22) d; t = - 2.511, P = 0.018]. Conclusions Atorvastatin can accelerate the absorption of epidual effusion and improve the prognosis after digital plastic titanium mesh cranioplasty. DOI:10.3969/j.issn.1672-6731.2019.09.012

Keywords

• epidual effusion (not in mesh)
• atorvastatin calcium
• skull
• neurosurgical procedures