DEN Open (Apr 2023)

Local recurrence of submucosal invasive colorectal cancer after endoscopic submucosal dissection revealed by copy number variation

  • Yu Okazawa,
  • Kiichi Sugimoto,
  • Yuki Ii,
  • Takahiro Irie,
  • Megumi Kawaguchi,
  • Aya Kobari,
  • Hirotaka Momose,
  • Yuki Tsuchiya,
  • Kota Amemiya,
  • Shunsuke Motegi,
  • Ryoichi Tsukamoto,
  • Kazumasa Kure,
  • Kumpei Honjo,
  • Hisashi Ro,
  • Rina Takahashi,
  • Shingo Kawano,
  • Masaya Kawai,
  • Shun Ishiyama,
  • Makoto Takahashi,
  • Yutaka Kojima,
  • Yuichi Tomiki,
  • Atsushi Arakawa,
  • Takashi Yao,
  • Kaishi Satomi,
  • Yuko Matsushita,
  • Koichi Ichimura,
  • Kazuhiro Sakamoto

DOI
https://doi.org/10.1002/deo2.208
Journal volume & issue
Vol. 3, no. 1
pp. n/a – n/a

Abstract

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Abstract We report a case in which analysis of copy number variation revealed local recurrence of submucosal invasive colorectal cancer after curative endoscopic submucosal dissection (ESD). An 86‐year‐old man with a history of abdominoperineal resection of the rectum for rectal cancer underwent resection with ESD for early‐stage sigmoid cancer 5 cm away from the stoma opening. At the same time, ileocecal resection was performed for advanced cecal cancer. Twelve months after ESD, advanced cancer occurred in the area of the ESD lesion. It was unclear if the cancer was a local recurrence after ESD, implantation of cecal cancer, or a new lesion. Copy number variation analysis performed for the three lesions revealed that the new lesion originated from residual tumor cells from ESD and was unlikely to be cecal cancer.

Keywords