Primary HIV-1 resistance: Persistence of transmitted drug resistance mutations

Abstract

Transmitted drug resistance (TDR) is one of the consequences of the high variability of HIV-1. The widespread use of antiretroviral therapy for the treatment of HIV-1 infection results in a large circulating pool of resistant virus variants. It is known that TDR mutations can persist for extended periods and may pose an important problem to the overall success of antiretroviral therapy. Factors that determine the duration of continuous persistence of resistance-associated mutations are the number and type of these mutations and their impact on viral fitness. Here we describe the follow-up of a case study of prolonged persistence of resistance-associated mutations, namely RT mutations Q151M, K65KR and Y181C conferring an intermediate-to-high level resistance to multiple NRTIs and NNRTIs that lasted for seven years. The infection was caused by subtype G virus. [Projekat Ministarstva nauke Republike SRbije, br. 175024 and The sixth framework European Commission European Commission grant LSHP CT-2006-518211]

Keywords

• HIV-1
• primary resistance
• Q151M complex
• viral fitness
• persistence