Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury

Hao Wei; Dawei Jiang; Bo Yu; Dalong Ni; Mengting Li; Yin Long; Paul A. Ellison; Cerise M. Siamof; Liang Cheng; Todd E. Barnhart; Hyung-Jun Im; Faquan Yu; Xiaoli Lan; Xiaohua Zhu; Qianjun He; Weibo Cai

Bioactive Materials (Jan 2023)

Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury

Hao Wei,
Dawei Jiang,
Bo Yu,
Dalong Ni,
Mengting Li,
Yin Long,
Paul A. Ellison,
Cerise M. Siamof,
Liang Cheng,
Todd E. Barnhart,
Hyung-Jun Im,
Faquan Yu,
Xiaoli Lan,
Xiaohua Zhu,
Qianjun He,
Weibo Cai

Affiliations

Hao Wei: Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Dawei Jiang: Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Bo Yu: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA; Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China
Dalong Ni: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Mengting Li: Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Yin Long: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Paul A. Ellison: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Cerise M. Siamof: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Liang Cheng: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China
Todd E. Barnhart: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Hyung-Jun Im: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA
Faquan Yu: Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China
Xiaoli Lan: Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Corresponding author.
Xiaohua Zhu: Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China; Corresponding author.
Qianjun He: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, China; Corresponding author.
Weibo Cai: Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA; University of Wisconsin Carbone Cancer Center, University of Wisconsin–Madison, Madison, WI, 53705, USA; Corresponding authors. Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA.

Journal volume & issue: Vol. 19
pp. 282 – 291

Abstract

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Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa), presenting a controllable delivery nanosystem for kidney targeting. Renal accumulation of the relatively small nanoparticles, 89Zr-PCurNP M10 with the diameter between 5 and 8 nm, is found to be 1.7 times and 1.8 times higher than the accumulation of 89Zr-PCurNP M29 (20–50 nm) and M40 (20–50 nm) as revealed by PET imaging. Furthermore, serum creatinine analysis, kidney tissues histology, and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI. Herein, PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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