A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

Akira Wiberg; Michael Ng; Annina B. Schmid; Robert W. Smillie; Georgios Baskozos; Michael V. Holmes; K. Künnapuu; R. Mägi; David L. Bennett; Dominic Furniss

doi:10.1038/s41467-019-08993-6

Nature Communications (Mar 2019)

A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

Akira Wiberg,
Michael Ng,
Annina B. Schmid,
Robert W. Smillie,
Georgios Baskozos,
Michael V. Holmes,
K. Künnapuu,
R. Mägi,
David L. Bennett,
Dominic Furniss

Affiliations

Akira Wiberg: Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Botnar Research Centre
Michael Ng: Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Botnar Research Centre
Annina B. Schmid: Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital
Robert W. Smillie: Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Botnar Research Centre
Georgios Baskozos: Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital
Michael V. Holmes: Medical Research Council Population Health Research Unit at the University of Oxford
K. Künnapuu: Institute of Technology, University of Tartu
R. Mägi: Estonian Genome Center, Institute of Genomics, University of Tartu
David L. Bennett: Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital
Dominic Furniss: Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Botnar Research Centre

DOI: https://doi.org/10.1038/s41467-019-08993-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Carpal tunnel syndrome (CTS) is caused by entrapment of the median nerve at the wrist. Here, Wiberg et al. perform a GWAS for CTS in the UK Biobank cohort and identify 16 genetic loci, and find a causal relationship between short stature and CTS risk using Mendelian randomisation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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