Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

Sarah Cooper; Anne Grijzenhout; Elizabeth Underwood; Katia Ancelin; Tianyi Zhang; Tatyana B. Nesterova; Burcu Anil-Kirmizitas; Andrew Bassett; Susanne M. Kooistra; Karl Agger; Kristian Helin; Edith Heard; Neil Brockdorff

doi:10.1038/ncomms13661

Nature Communications (Nov 2016)

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

Sarah Cooper,
Anne Grijzenhout,
Elizabeth Underwood,
Katia Ancelin,
Tianyi Zhang,
Tatyana B. Nesterova,
Burcu Anil-Kirmizitas,
Andrew Bassett,
Susanne M. Kooistra,
Karl Agger,
Kristian Helin,
Edith Heard,
Neil Brockdorff

Affiliations

Sarah Cooper: Department of Biochemistry, Developmental Epigenetics, University of Oxford
Anne Grijzenhout: Department of Biochemistry, Developmental Epigenetics, University of Oxford
Elizabeth Underwood: Department of Biochemistry, Developmental Epigenetics, University of Oxford
Katia Ancelin: Institut Curie, CNRS UMR3215, INSERM U934
Tianyi Zhang: Department of Biochemistry, Developmental Epigenetics, University of Oxford
Tatyana B. Nesterova: Department of Biochemistry, Developmental Epigenetics, University of Oxford
Burcu Anil-Kirmizitas: Department of Biochemistry, Developmental Epigenetics, University of Oxford
Andrew Bassett: Genome Engineering Oxford, Sir William Dunn School of Pathology, University of Oxford
Susanne M. Kooistra: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Karl Agger: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Kristian Helin: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Edith Heard: Institut Curie, CNRS UMR3215, INSERM U934
Neil Brockdorff: Department of Biochemistry, Developmental Epigenetics, University of Oxford

DOI: https://doi.org/10.1038/ncomms13661
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental regulation of the genome in multicellular organisms. Here the authors describe how the PRC2 cofactor Jarid2 mediates the recruitment of the PRC2 complex to chromatin via interaction with H2AK119u1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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