Evaluation of allergenic properties and immunotoxicity of dipeptide mimetic of brain-derived neurotrophic factor GSB-106

Abstract

Abstract. The study of allergenic properties and immunotoxic effects of the ready-to-use drug form of GSB-106 was carried out. The study of allergenic properties and immunotoxicity of GSB-106 was performed on male albino guinea pigs weighing 250-300 g and on male CBA, C57BL / 6, F1 hybrids (CBAxC57BL / 6) mice. When assessing immunotoxicity, GSB-106 was inject to mice per os for 14 days in doses of 2.2 mg / kg and 22 mg / kg. When studying the allergenicity, GSB-106 was injected to albino guinea pigs in doses of 1 mg / kg and 10 mg / kg according to standard regimens of immunization. The results of the study of the immunotoxicity and allergenicity of GSB-106 allow us to conclude that the injection of the ready-to-use drug form of GSB-106 in the range of studied doses does not have an immunotoxic effect and does not have allergenic properties.

Keywords

• dipeptide mimetic of brain-derived neurotrophic factor gsb-106
• phagocytosis
• chemiluminescence
• humoral immune response
• cellular immune response
• immunotoxicity
• systemic anaphylaxis
• delayed hypersensitivity
• concanavalin а-induced inflammation