Journal of Inflammation Research (Aug 2021)

Insights into the Implications of Coexisting Type 2 Inflammatory Diseases

  • McCormick JP,
  • Lee JT

Journal volume & issue
Vol. Volume 14
pp. 4259 – 4266

Abstract

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Justin P McCormick, Jivianne T Lee Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USACorrespondence: Jivianne T LeeDepartment of Head and Neck Surgery, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USAEmail [email protected]: The role of type 2 inflammation in the pathogenesis of certain human diseases is an area of active investigation. Certain asthma, atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis phenotypes are characterized by a Th2 predominant inflammatory pathway and are frequently associated with comorbid conditions in patients. The purpose of this article is to review the evidence behind concurrent Th2-mediated diseases and explore how the presence of these comorbid conditions affect patient and disease outcomes.Keywords: type 2 inflammation, Th2 inflammation, asthma, atopic dermatitis, eosinophilic esophagitis, chronic rhinosinusitis

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