Journal of Laboratory Medicine (Jun 2024)
Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) – a prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients
- Sommer Sebastian,
- Schmutz Maximilian,
- Hildebrand Kathrin,
- Schiwitza Annett,
- Benedikt Selinah,
- Eberle Maria,
- Mögele Tatiana,
- Sultan Aziz,
- Reichl Lena,
- Campillo Maria,
- Uhrmacher Luise,
- Nikolic Ana Antic,
- Bundschuh Ralph,
- Lapa Constantin,
- Kuhlen Michaela,
- Dintner Sebastian,
- Langer Angela,
- Märkl Bruno,
- Wendler Thomas,
- Tehlan Kartikay,
- Kröncke Thomas,
- Wahle Maria,
- Mann Matthias,
- Casadei Nicolas,
- Pogoda Michaela,
- Hummler Simone,
- Sax Irmengard,
- Schlesner Matthias,
- Kubuschok Boris,
- Trepel Martin,
- Claus Rainer
Affiliations
- Sommer Sebastian
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Schmutz Maximilian
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Hildebrand Kathrin
- Pathology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Schiwitza Annett
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Benedikt Selinah
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Eberle Maria
- Pathology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Mögele Tatiana
- Pathology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Sultan Aziz
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Reichl Lena
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Campillo Maria
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Uhrmacher Luise
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Nikolic Ana Antic
- Nuclear Medicine, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Bundschuh Ralph
- Nuclear Medicine, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Lapa Constantin
- Nuclear Medicine, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Kuhlen Michaela
- Pediatric and Adolescent Medicine, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Dintner Sebastian
- Pathology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Langer Angela
- Pathology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Märkl Bruno
- Pathology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Wendler Thomas
- Department of Diagnostic and Interventional Radiology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Tehlan Kartikay
- Department of Diagnostic and Interventional Radiology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Kröncke Thomas
- Bavarian Cancer Research Center (BZKF), Augsburg, Germany
- Wahle Maria
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
- Mann Matthias
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
- Casadei Nicolas
- Institute of Medical Genetics and Applied Genomics, 27203University Hospital Tübingen, Tübingen, Germany
- Pogoda Michaela
- Institute of Medical Genetics and Applied Genomics, 27203University Hospital Tübingen, Tübingen, Germany
- Hummler Simone
- Clinical Trials Office (KKS), Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Sax Irmengard
- Biomedical Informatics, Data Mining and Data Analytics, 26522University of Augsburg, Augsburg, Germany
- Schlesner Matthias
- Biomedical Informatics, Data Mining and Data Analytics, 26522University of Augsburg, Augsburg, Germany
- Kubuschok Boris
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Trepel Martin
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- Claus Rainer
- Hematology and Oncology, Faculty of Medicine, 26522University of Augsburg, Augsburg, Germany
- DOI
- https://doi.org/10.1515/labmed-2023-0156
- Journal volume & issue
-
Vol. 48,
no. 3
pp. 107 – 119
Abstract
Liquid biopsy (LBx) provides diagnostic, prognostic and predictive insights for malignant diseases and offers promising applications regarding tumor burden, tumor heterogeneity and clonal evolution.
Keywords
- liquid biopsy
- ctdna
- longitudinal profiling
- clonal evolution
- spatial heterogeneity
- translational research
