Nature Communications (Dec 2016)

Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish

  • Chenglu Xiao,
  • Lu Gao,
  • Yu Hou,
  • Congfei Xu,
  • Nannan Chang,
  • Fang Wang,
  • Keping Hu,
  • Aibin He,
  • Ying Luo,
  • Jun Wang,
  • Jinrong Peng,
  • Fuchou Tang,
  • Xiaojun Zhu,
  • Jing-Wei Xiong

DOI
https://doi.org/10.1038/ncomms13787
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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The adult zebrafish heart is capable of regeneration but the molecular mechanisms are poorly understood. Here the authors show that chromatin remodeling factor Brg1 represses cyclin-dependent kinase inhibitors to promote myocardial regeneration.