Communications Biology (May 2021)

High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation

  • Jenny N. Tran,
  • Oliver P. Günther,
  • Karen R. Sherwood,
  • Franz Fenninger,
  • Lenka L. Allan,
  • James Lan,
  • Ruth Sapir-Pichhadze,
  • Rene Duquesnoy,
  • Frans Claas,
  • Steven G. E. Marsh,
  • W. Robert McMaster,
  • Paul A. Keown,
  • Genome Canada Transplant Consortium

DOI
https://doi.org/10.1038/s42003-021-01989-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national transplantation program.