Communications Biology (May 2021)
High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
Abstract
Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national transplantation program.