Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
Ichrak Souii,
Med Abderrahmane Sanhoury,
Javier Vicario,
Xabier Jiménez-Aberásturi,
Mohamed L. Efrit,
Hedi M’rabet,
Jesús M. de los Santos
Affiliations
Ichrak Souii
Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia
Med Abderrahmane Sanhoury
Laboratory of Structural Organic Chemistry: Synthesis and Physicochemical Studies, Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, El Manar I, Tunis 2092, Tunisia
Javier Vicario
Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain
Xabier Jiménez-Aberásturi
Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain
Mohamed L. Efrit
Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia
Hedi M’rabet
Laboratory of Selective Organic & Heterocyclic Synthesis Biological Activity Evaluation (LR17ES01), Department of Chemistry, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia
Jesús M. de los Santos
Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria, Spain
Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of bis(α-aminophosphonates) prepared and ethyl (2-bromomethyl)acrylate under mild reaction conditions afforded an original synthetic approach to a new series of bis(allylic-α-aminophosphonates).
