Nature Communications (Oct 2022)
Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses
- Janice Zhirong Jia,
- Chee Wah Tan,
- Samuel M. S. Cheng,
- Haogao Gu,
- Aileen Ying Yan Yeoh,
- Chris Ka Pun Mok,
- Yanqun Wang,
- Jincun Zhao,
- Nancy H. L. Leung,
- Benjamin J. Cowling,
- Leo L. M. Poon,
- David S. C. Hui,
- Linfa Wang,
- Malik Peiris,
- Sophie A. Valkenburg
Affiliations
- Janice Zhirong Jia
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chee Wah Tan
- Duke-NUS Medical School, National University of Singapore
- Samuel M. S. Cheng
- School of Public Health, The University of Hong Kong
- Haogao Gu
- School of Public Health, The University of Hong Kong
- Aileen Ying Yan Yeoh
- Duke-NUS Medical School, National University of Singapore
- Chris Ka Pun Mok
- The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong
- Yanqun Wang
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Jincun Zhao
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Nancy H. L. Leung
- WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Benjamin J. Cowling
- WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Leo L. M. Poon
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- David S. C. Hui
- Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Linfa Wang
- Duke-NUS Medical School, National University of Singapore
- Malik Peiris
- School of Public Health, The University of Hong Kong
- Sophie A. Valkenburg
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-022-34038-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Vaccination and infection history determine the breadth of neutralizing antibody response to SARS-CoV-2 variants and other sarbecoviruses with breakthrough or natural infection combined with vaccination or booster vaccination with mRNA vaccine providing highest neutralization.
