CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion

Zhiqian Li; Nimi Marcel; Sushil Devkota; Ankush Auradkar; Stephen M. Hedrick; Valentino M. Gantz; Ethan Bier

doi:10.1038/s41467-021-22927-1

Nature Communications (May 2021)

CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion

Zhiqian Li,
Nimi Marcel,
Sushil Devkota,
Ankush Auradkar,
Stephen M. Hedrick,
Valentino M. Gantz,
Ethan Bier

Affiliations

Zhiqian Li: Section of Cell and Developmental Biology, University of California San Diego
Nimi Marcel: Section of Molecular Biology, University of California San Diego
Sushil Devkota: Section of Cell and Developmental Biology, University of California San Diego
Ankush Auradkar: Section of Cell and Developmental Biology, University of California San Diego
Stephen M. Hedrick: Section of Molecular Biology, University of California San Diego
Valentino M. Gantz: Section of Cell and Developmental Biology, University of California San Diego
Ethan Bier: Section of Cell and Developmental Biology, University of California San Diego

DOI: https://doi.org/10.1038/s41467-021-22927-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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CRISPR-based genetic elements can copy themselves across host genomes. Here the authors introduce CopyCatcher, a gene-drive related system for detecting and quantifying somatic gene conversion events.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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