DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation

Yunyun An; Xin Zhao; Ziteng Zhang; Zhaohua Xia; Mengqi Yang; Li Ma; Yu Zhao; Gang Xu; Shunda Du; Xiang’an Wu; Shuowen Zhang; Xin Hong; Xin Jin; Kun Sun

doi:10.1038/s41467-023-35959-6

Nature Communications (Jan 2023)

DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation

Yunyun An,
Xin Zhao,
Ziteng Zhang,
Zhaohua Xia,
Mengqi Yang,
Li Ma,
Yu Zhao,
Gang Xu,
Shunda Du,
Xiang’an Wu,
Shuowen Zhang,
Xin Hong,
Xin Jin,
Kun Sun

Affiliations

Yunyun An: Institute of Cancer Research, Shenzhen Bay Laboratory
Xin Zhao: Hepato-Biliary Surgery Division, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, Southern University of Science and Technology
Ziteng Zhang: Hepato-Biliary Surgery Division, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, Southern University of Science and Technology
Zhaohua Xia: Thoracic Surgical Department, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, Southern University of Science and Technology
Mengqi Yang: Institute of Cancer Research, Shenzhen Bay Laboratory
Li Ma: Institute of Cancer Research, Shenzhen Bay Laboratory
Yu Zhao: Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Gang Xu: Department of Liver Surgery and Liver Transplant Center, West China Hospital of Sichuan University
Shunda Du: Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences
Xiang’an Wu: Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences
Shuowen Zhang: Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences
Xin Hong: Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Xin Jin: BGI-Shenzhen
Kun Sun: Institute of Cancer Research, Shenzhen Bay Laboratory

DOI: https://doi.org/10.1038/s41467-023-35959-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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Cell free DNA is produced through a non-random process. Here, the authors use orientation-aware fragmentation analysis to identify DNA methylation as a regulator of nuclease function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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