254 CTLA-4 blockade promotes Treg glucose metabolism and reduces Treg functional stability in glycolysis-defective tumors

• Yasin Senbabaoglu,
• Greg Delgoffe,
• Ping-Chih Ho,
• Arnab Ghosh,
• Svena Verma,
• McLane Watson,
• Inna Serganova,
• Ivan Cohen,
• Masatomo Maeda,
• Masahiro Shindo,
• Rachana Maniyar,
• Mayuresh Mane,
• Avigdor Leftin,
• Matthew Lubin,
• Myat Kyaw Ko,
• Mohsen Abu-Akeel,
• Ellen Ackerstaff,
• Jason Koutcher,
• Ronald Blasberg

Affiliations

Yasin Senbabaoglu

Aff169 grid.51462.340000000121719952Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center New York NY USA

Greg Delgoffe

Aff236 grid.21925.3d0000000419369000University of Pittsburgh Pittsburgh PA USA

Ping-Chih Ho

Aff3 0000000419368710grid.47100.32Department of ImmunobiologyYale School of Medicine 06510 New Haven CT USA

Arnab Ghosh

1Memorial Sloan Kettering Cancer Center, New York, NY, USA

Svena Verma

1Memorial Sloan Kettering Cancer Center, New York, NY, USA

McLane Watson

University of Pittsburgh SOM, Pittsburgh, Pennsylvania, USA

Inna Serganova

1Memorial Sloan Kettering Cancer Center, New York, USA

Ivan Cohen

1Memorial Sloan Kettering Cancer Center, New York, USA

Masatomo Maeda

1Memorial Sloan Kettering Cancer Center, New York, USA

Masahiro Shindo

1Memorial Sloan Kettering Cancer Center, New York, USA

Rachana Maniyar

1Memorial Sloan Kettering Cancer Center, New York, USA

Mayuresh Mane

1Memorial Sloan Kettering Cancer Center, New York, USA

Avigdor Leftin

1Memorial Sloan Kettering Cancer Center, New York, USA

Matthew Lubin

1Memorial Sloan Kettering Cancer Center, New York, USA

Myat Kyaw Ko

1Memorial Sloan Kettering Cancer Center, New York, USA

Mohsen Abu-Akeel

1Memorial Sloan Kettering Cancer Center, New York, USA

Ellen Ackerstaff

1Memorial Sloan Kettering Cancer Center, New York, USA

Jason Koutcher

1Memorial Sloan Kettering Cancer Center, New York, USA

Ronald Blasberg

1Memorial Sloan Kettering Cancer Center, New York, USA