Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis

Abstract

Abstract Objective Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China; furthermore, >80% of cases worldwide occur in South China. This study analyzed the use of peripheral blood inflammatory markers as prognostic factors in patients with local recurrence and distant metastasis after radiochemotherapy for NPC. Methods A retrospective analysis was carried out on the prognosis of 99 NPC patients with pathological and imaging diagnosis after radiochemotherapy at The First Affiliated Hospital of Nanchang University between 2010 and 2018．The Kaplan–Meier method was used to calculate survival rates, log–rank tests were used for univariate prognostic analysis, and a Cox regression model was used for multivariate prognostic analysis. Results Univariate analysis showed that treatment plan (χ2 = 8.895, P = 0.003), primary platelet count (χ2 = 3.92, P = 0.048), and primary lactate dehydrogenase level (LDH; χ2 = 22.138, P < 0.001) were positively correlated with survival time. Multivariable analysis showed that treatment plan (hazard ratio 2.103, 95% confidence interval 1.276 to –3.469, P = 0.004) and LDH (hazard ratio 2.711, 95% confidence interval 1.714–4.289, P < 0.001) were independent risk factors for NPC. Conclusions Treatment plan, primary platelet count, and primary LDH were positively correlated with survival time. Treatment plan and primary LDH level were independent risk factors for patients with recurrent or metastatic nasopharyngeal carcinoma.

Keywords

• metastatic
• nasopharyngeal carcinoma
• prognosis
• recurrent