Hepatitis B virus cccDNA is formed through distinct repair processes of each strand

Lei Wei; Alexander Ploss

doi:10.1038/s41467-021-21850-9

Nature Communications (Mar 2021)

Hepatitis B virus cccDNA is formed through distinct repair processes of each strand

Lei Wei,
Alexander Ploss

Affiliations

Lei Wei: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University
Alexander Ploss: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University

DOI: https://doi.org/10.1038/s41467-021-21850-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is converted into cccDNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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