B‑nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner

• Andreas Stein,
• Persefoni Hilken née Thomopoulou,
• Corazon Frias,
• Sina M. Hopff,
• Paloma Varela,
• Nicola Wilke,
• Arul Mariappan,
• Jörg-Martin Neudörfl,
• Alexey Yu Fedorov,
• Jay Gopalakrishnan,
• Benoît Gigant,
• Aram Prokop,
• Hans-Günther Schmalz

Affiliations

Andreas Stein

Department of Chemistry, University of Cologne, Cologne, Germany

Persefoni Hilken née Thomopoulou

Department of Chemistry, University of Cologne, Cologne, Germany

Corazon Frias

Department of Paediatric Oncology, Children’s Hospital Cologne, Cologne, Germany

Sina M. Hopff

Department of Paediatric Oncology, Children’s Hospital Cologne, Cologne, Germany

Paloma Varela

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France

Nicola Wilke

Department of Paediatric Oncology, Children’s Hospital Cologne, Cologne, Germany

Arul Mariappan

Laboratory for Centrosome and Cytoskeleton Biology, Institute of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany

Jörg-Martin Neudörfl

Department of Chemistry, University of Cologne, Cologne, Germany

Alexey Yu Fedorov

Department of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation

Jay Gopalakrishnan

Laboratory for Centrosome and Cytoskeleton Biology, Institute of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany

Benoît Gigant

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France

Aram Prokop

Department of Paediatric Oncology, Children’s Hospital Cologne, Cologne, Germany

Hans-Günther Schmalz

Department of Chemistry, University of Cologne, Cologne, Germany