Nature Communications (Oct 2021)
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
- Wei-Yu Lin,
- Sarah E. Fordham,
- Eric Hungate,
- Nicola J. Sunter,
- Claire Elstob,
- Yaobo Xu,
- Catherine Park,
- Anne Quante,
- Konstantin Strauch,
- Christian Gieger,
- Andrew Skol,
- Thahira Rahman,
- Lara Sucheston-Campbell,
- Junke Wang,
- Theresa Hahn,
- Alyssa I. Clay-Gilmour,
- Gail L. Jones,
- Helen J. Marr,
- Graham H. Jackson,
- Tobias Menne,
- Mathew Collin,
- Adam Ivey,
- Robert K. Hills,
- Alan K. Burnett,
- Nigel H. Russell,
- Jude Fitzgibbon,
- Richard A. Larson,
- Michelle M. Le Beau,
- Wendy Stock,
- Olaf Heidenreich,
- Abrar Alharbi,
- David J. Allsup,
- Richard S. Houlston,
- Jean Norden,
- Anne M. Dickinson,
- Elisabeth Douglas,
- Clare Lendrem,
- Ann K. Daly,
- Louise Palm,
- Kim Piechocki,
- Sally Jeffries,
- Martin Bornhäuser,
- Christoph Röllig,
- Heidi Altmann,
- Leo Ruhnke,
- Desiree Kunadt,
- Lisa Wagenführ,
- Heather J. Cordell,
- Rebecca Darlay,
- Mette K. Andersen,
- Maria C. Fontana,
- Giovanni Martinelli,
- Giovani Marconi,
- Miguel A. Sanz,
- José Cervera,
- Inés Gómez-Seguí,
- Thomas Cluzeau,
- Chimène Moreilhon,
- Sophie Raynaud,
- Heinz Sill,
- Maria Teresa Voso,
- Francesco Lo-Coco,
- Hervé Dombret,
- Meyling Cheok,
- Claude Preudhomme,
- Rosemary E. Gale,
- David Linch,
- Julia Gaal-Wesinger,
- Andras Masszi,
- Daniel Nowak,
- Wolf-Karsten Hofmann,
- Amanda Gilkes,
- Kimmo Porkka,
- Jelena D. Milosevic Feenstra,
- Robert Kralovics,
- David Grimwade,
- Manja Meggendorfer,
- Torsten Haferlach,
- Szilvia Krizsán,
- Csaba Bödör,
- Friedrich Stölzel,
- Kenan Onel,
- James M. Allan
Affiliations
- Wei-Yu Lin
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Sarah E. Fordham
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Eric Hungate
- Section of Pediatric Hematology and Oncology, University of Chicago
- Nicola J. Sunter
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Claire Elstob
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Yaobo Xu
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Catherine Park
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Anne Quante
- Helmholtz Zentrum München, German Research Center for Environmental Health
- Konstantin Strauch
- Helmholtz Zentrum München, German Research Center for Environmental Health
- Christian Gieger
- Ludwig-Maximilians-Universität München, Chair of Genetic Epidemiology, IBE, Faculty of Medicine
- Andrew Skol
- Section of Pediatric Hematology and Oncology, University of Chicago
- Thahira Rahman
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Lara Sucheston-Campbell
- College of Pharmacy, The Ohio State University
- Junke Wang
- College of Pharmacy, The Ohio State University
- Theresa Hahn
- Department of Medicine, Roswell Park Cancer Institute
- Alyssa I. Clay-Gilmour
- Arnold School of Public Health, Department of Epidemiology & Biostatistics, University of South Carolina
- Gail L. Jones
- Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust
- Helen J. Marr
- Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust
- Graham H. Jackson
- Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust
- Tobias Menne
- Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust
- Mathew Collin
- Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust
- Adam Ivey
- Department of Medical and Molecular Genetics, King’s College Medical School
- Robert K. Hills
- Nuffield Department of Population Health, University of Oxford
- Alan K. Burnett
- Paul O’Gorman Leukaemia Research Centre, University of Glasgow
- Nigel H. Russell
- Department of Haematology, Nottingham University Hospitals NHS Trust
- Jude Fitzgibbon
- Barts Cancer Institute, Queen Mary University of London
- Richard A. Larson
- Section of Pediatric Hematology and Oncology, University of Chicago
- Michelle M. Le Beau
- Section of Pediatric Hematology and Oncology, University of Chicago
- Wendy Stock
- Section of Pediatric Hematology and Oncology, University of Chicago
- Olaf Heidenreich
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Abrar Alharbi
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- David J. Allsup
- Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Jean Norden
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Anne M. Dickinson
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Elisabeth Douglas
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Clare Lendrem
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Ann K. Daly
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Louise Palm
- West Midlands Regional Genetics Laboratory, Birmingham Women’s Hospital
- Kim Piechocki
- West Midlands Regional Genetics Laboratory, Birmingham Women’s Hospital
- Sally Jeffries
- West Midlands Regional Genetics Laboratory, Birmingham Women’s Hospital
- Martin Bornhäuser
- Department of Haematological Medicine, The Rayne Institute, King’s College London
- Christoph Röllig
- Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden
- Heidi Altmann
- Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden
- Leo Ruhnke
- Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden
- Desiree Kunadt
- Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden
- Lisa Wagenführ
- Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden
- Heather J. Cordell
- Population Health Sciences Institute, Newcastle University
- Rebecca Darlay
- Population Health Sciences Institute, Newcastle University
- Mette K. Andersen
- Department of Clinical Genetics, University Hospital Rigshospitalet
- Maria C. Fontana
- Institute of Hematology “L. and A. Seràgnoli”, University of Bologna
- Giovanni Martinelli
- IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”
- Giovani Marconi
- IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”
- Miguel A. Sanz
- Hematology Service, Hospital Universitario y Politécnico La Fe
- José Cervera
- Hematology Service, Hospital Universitario y Politécnico La Fe
- Inés Gómez-Seguí
- Hematology Service, Hospital Universitario y Politécnico La Fe
- Thomas Cluzeau
- Hematology department, Cote d’Azur University, CHU of Nice
- Chimène Moreilhon
- Hematology department, Cote d’Azur University, CHU of Nice
- Sophie Raynaud
- Hematology department, Cote d’Azur University, CHU of Nice
- Heinz Sill
- Division of Hematology, Medical University of Graz
- Maria Teresa Voso
- Università di Roma Tor Vergata, Dipartimento di Biomedicina e Prevenzione
- Francesco Lo-Coco
- Università di Roma Tor Vergata, Dipartimento di Biomedicina e Prevenzione
- Hervé Dombret
- Hôpital Saint-Louis, Institut Universitaire d’Hématologie, Université Paris Diderot
- Meyling Cheok
- Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer
- Claude Preudhomme
- Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer
- Rosemary E. Gale
- Department of Haematology, University College London Cancer Institute
- David Linch
- Department of Haematology, University College London Cancer Institute
- Julia Gaal-Wesinger
- 1st Department of Internal Medicine, Semmewleis University
- Andras Masszi
- 3rd Department of Internal Medicine, Semmewleis University
- Daniel Nowak
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Wolf-Karsten Hofmann
- Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University
- Amanda Gilkes
- Department of Haematology, University of Cardiff
- Kimmo Porkka
- Helsinki University Hospital Comprehensive Cancer Center, Hematology Research Unit Helsinki, University of Helsinki
- Jelena D. Milosevic Feenstra
- Department of Laboratory Medicine, Medical University of Vienna
- Robert Kralovics
- Department of Laboratory Medicine, Medical University of Vienna
- David Grimwade
- Department of Medical and Molecular Genetics, King’s College Medical School
- Manja Meggendorfer
- MLL Munich Leukemia Laboratory
- Torsten Haferlach
- MLL Munich Leukemia Laboratory
- Szilvia Krizsán
- HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University
- Csaba Bödör
- HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University
- Friedrich Stölzel
- Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden
- Kenan Onel
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- James M. Allan
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- DOI
- https://doi.org/10.1038/s41467-021-26551-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.
