Nature Communications (Oct 2021)

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

  • Wei-Yu Lin,
  • Sarah E. Fordham,
  • Eric Hungate,
  • Nicola J. Sunter,
  • Claire Elstob,
  • Yaobo Xu,
  • Catherine Park,
  • Anne Quante,
  • Konstantin Strauch,
  • Christian Gieger,
  • Andrew Skol,
  • Thahira Rahman,
  • Lara Sucheston-Campbell,
  • Junke Wang,
  • Theresa Hahn,
  • Alyssa I. Clay-Gilmour,
  • Gail L. Jones,
  • Helen J. Marr,
  • Graham H. Jackson,
  • Tobias Menne,
  • Mathew Collin,
  • Adam Ivey,
  • Robert K. Hills,
  • Alan K. Burnett,
  • Nigel H. Russell,
  • Jude Fitzgibbon,
  • Richard A. Larson,
  • Michelle M. Le Beau,
  • Wendy Stock,
  • Olaf Heidenreich,
  • Abrar Alharbi,
  • David J. Allsup,
  • Richard S. Houlston,
  • Jean Norden,
  • Anne M. Dickinson,
  • Elisabeth Douglas,
  • Clare Lendrem,
  • Ann K. Daly,
  • Louise Palm,
  • Kim Piechocki,
  • Sally Jeffries,
  • Martin Bornhäuser,
  • Christoph Röllig,
  • Heidi Altmann,
  • Leo Ruhnke,
  • Desiree Kunadt,
  • Lisa Wagenführ,
  • Heather J. Cordell,
  • Rebecca Darlay,
  • Mette K. Andersen,
  • Maria C. Fontana,
  • Giovanni Martinelli,
  • Giovani Marconi,
  • Miguel A. Sanz,
  • José Cervera,
  • Inés Gómez-Seguí,
  • Thomas Cluzeau,
  • Chimène Moreilhon,
  • Sophie Raynaud,
  • Heinz Sill,
  • Maria Teresa Voso,
  • Francesco Lo-Coco,
  • Hervé Dombret,
  • Meyling Cheok,
  • Claude Preudhomme,
  • Rosemary E. Gale,
  • David Linch,
  • Julia Gaal-Wesinger,
  • Andras Masszi,
  • Daniel Nowak,
  • Wolf-Karsten Hofmann,
  • Amanda Gilkes,
  • Kimmo Porkka,
  • Jelena D. Milosevic Feenstra,
  • Robert Kralovics,
  • David Grimwade,
  • Manja Meggendorfer,
  • Torsten Haferlach,
  • Szilvia Krizsán,
  • Csaba Bödör,
  • Friedrich Stölzel,
  • Kenan Onel,
  • James M. Allan

DOI
https://doi.org/10.1038/s41467-021-26551-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.