Macrophage-released ADAMTS1 promotes muscle stem cell activation

Hongqing Du; Chung-Hsuan Shih; Michael N. Wosczyna; Alisa A. Mueller; Joonseok Cho; Abhishek Aggarwal; Thomas A. Rando; Brian J. Feldman

doi:10.1038/s41467-017-00522-7

Nature Communications (Sep 2017)

Macrophage-released ADAMTS1 promotes muscle stem cell activation

Hongqing Du,
Chung-Hsuan Shih,
Michael N. Wosczyna,
Alisa A. Mueller,
Joonseok Cho,
Abhishek Aggarwal,
Thomas A. Rando,
Brian J. Feldman

Affiliations

Hongqing Du: Department of Pediatrics, Stanford University
Chung-Hsuan Shih: Department of Pediatrics, Stanford University
Michael N. Wosczyna: Department of Neurology and Neurological Sciences, Stanford University
Alisa A. Mueller: Department of Neurology and Neurological Sciences, Stanford University
Joonseok Cho: Department of Pediatrics, Stanford University
Abhishek Aggarwal: Department of Pediatrics, Stanford University
Thomas A. Rando: Department of Neurology and Neurological Sciences, Stanford University
Brian J. Feldman: Department of Pediatrics, Stanford University

DOI: https://doi.org/10.1038/s41467-017-00522-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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