Prognosis and predictors of convulsion among pediatric lupus nephritis patients

Abstract

In this study, we aimed to analyze features and outcome of convulsion in pediatric lupus nephritis patients. We retrospectively reviewed data of 14 Iranian children with lupus nephritis who developed seizures and compared them with a group of the same number of well matched pe-diatric lupus nephritis patients. Higher serum creatinine levels and higher frequencies of anemia and lymphopenia were observed in the convulsion group. Multivariable logistic regression analysis re-vealed that the only risk factor for development of convulsion in pediatric lupus patients with ne-phritis was lymphopenia. Survival analysis showed that convulsion had no impact on patient and renal function outcomes in our pediatric lupus nephritis subjects. In conclusion, we found that lympho-penia is a predictive factor for convulsion occurrence in our patients and special attention to neuro-logical status assessment may be needed in this situation.

Keywords

• Pediatric
• Childhood
• SLE
• Lupus nephritis
• Convulsion
• Neurological manifestations