Nature Communications (Sep 2016)
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
- Wenbin Zhong,
- Qing Yi,
- Bing Xu,
- Shiqian Li,
- Tong Wang,
- Fupei Liu,
- Biying Zhu,
- Peter R. Hoffmann,
- Guangju Ji,
- Pingsheng Lei,
- Guoping Li,
- Jiwei Li,
- Jian Li,
- Vesa M. Olkkonen,
- Daoguang Yan
Affiliations
- Wenbin Zhong
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- Qing Yi
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Bing Xu
- Department of Hematology, Nanfang Hospital, Southern Medical University
- Shiqian Li
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- Tong Wang
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- Fupei Liu
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- Biying Zhu
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- Peter R. Hoffmann
- Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii
- Guangju Ji
- National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Pingsheng Lei
- State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences
- Guoping Li
- The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology & Beijing Institute of Geriatrics, Ministry of Health
- Jiwei Li
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- Jian Li
- The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology & Beijing Institute of Geriatrics, Ministry of Health
- Vesa M. Olkkonen
- Minerva Foundation Institute for Medical Research
- Daoguang Yan
- Department of Biotechnology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University
- DOI
- https://doi.org/10.1038/ncomms12702
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Lymphocytic leukaemia cells are characterized by high respiratory rates. Here, the authors report that the oxysterol-binding protein ORPL4 sustains mitochondrial respiration in T-cell acute lymphoblastic leukaemia cells by regulating Ca2+release from the endoplasmic reticulum.
