Journal of Inflammation Research (Dec 2023)

Changes in Laboratory Indexes for Multiple Myeloma Patients Before and After Autologous Stem Cell Transplant

  • Zhao R,
  • Zhao J,
  • Song Y,
  • Fu W,
  • Wang Q,
  • Zhang R

Journal volume & issue
Vol. Volume 16
pp. 5779 – 5789

Abstract

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Rui Zhao, Jing Zhao, Yichuan Song, Wenxuan Fu, Qingtao Wang, Rui Zhang Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Qingtao Wang; Rui Zhang, Department of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, No. 8, Gongtinan Road, Chao-Yang District, Beijing, 100020, People’s Republic of China, Tel +86 1085231660, Email [email protected]; [email protected]: Outcomes after autologous stem cell transplantation (ASCT) are quite variable and difficult to predict. Second-generation flow, second-generation sequencing, and other tests are invasive and expensive for patients. In this study, we aimed to analyze laboratory data before and after transplantation to look for laboratory indicators that could predict disease progression in patients with newly diagnosed multiple myeloma (NDMM) patients underwent ASCT.Patients and Methods: Standard complete blood count (CBC) parameters, clinical biochemical, and immunological indicators on day -5 and day 90 after ASCT were obtained. Receiver-operating characteristic (ROC) curve was used to determine the cutoff values, we evaluated the predictive abilities of laboratory parameters for progression-free survival (PFS). Univariate and multivariate analyses were performed to evaluate the prognostic significance of variables associated with the PFS of 166 NDMM who underwent ASCT.Results: At day-5, a low absolute monocyte count (AMC, p=0.001), systemic inflammation response index< 1.56 (SIRI, P=0.03), serum calcium (p=0.02), and albumin (p=0.006) can predict for superior PFS. At Day +90, a high absolute neutrophil count (ANC, p = 0.008) and lymphocyte-to-monocyte ratio (LMR, p = 0.02), a low neutrophil-to-lymphocyte ratio (NLR, p =0.02) and SIRI< 0.41 (p=0.02) predicted for superior PFS.Conclusion: There are inflammation-related indicators derived from peripheral blood cell count (WBCC) – ANC, NLR, SIRI, and LMR - which can serve as potential biomarkers for predicting PFS of NDMM patients underwent ASCT.Keywords: multiple myeloma, autologous stem cell transplantation, SIRI, lymphocyte-to-monocyte ratio

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