Journal of the Serbian Chemical Society (Jan 2001)

Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors

  • Aleksić Mirjana B.,
  • Agbaba Danica G.,
  • Baošić Rada M.,
  • Milojković-Opsenica Dušanka M.,
  • Tešić Živoslav Lj.

Journal volume & issue
Vol. 66, no. 1
pp. 39 – 44


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Arapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2-methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1- N- 1-(ethoxycarbonyl)-3-phenylpropyl -L-alanyl -L-proline, Lisinopril - (S) -1- N2-(carboxy-3-phenylpropyl)-L-lysyl-L-proline, Quinapril - 3S-2R