MYCN protein stability is a better prognostic indicator in neuroblastoma

Yi Yang; Jie Zhao; Yingwen Zhang; Tianyue Feng; Bo Yv; Jing Wang; Yijin Gao; Minzhi Yin; Jingyan Tang; Yanxin Li

doi:10.1186/s12887-022-03449-1

BMC Pediatrics (Jul 2022)

MYCN protein stability is a better prognostic indicator in neuroblastoma

Yi Yang,
Jie Zhao,
Yingwen Zhang,
Tianyue Feng,
Bo Yv,
Jing Wang,
Yijin Gao,
Minzhi Yin,
Jingyan Tang,
Yanxin Li

Affiliations

Yi Yang: Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology
Jie Zhao: Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology
Yingwen Zhang: Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology
Tianyue Feng: Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology
Bo Yv: State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
Jing Wang: Department of general Surgery/Surgical Oncology Center, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
Yijin Gao: Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology
Minzhi Yin: Department of Pathology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
Jingyan Tang: Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology
Yanxin Li: Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology

DOI: https://doi.org/10.1186/s12887-022-03449-1
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 11

Abstract

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Highlights The MYCN gene test is most valuable for INSS stage 3 patients to predict prognosis. Compared to gene status, MYCN protein expression is more relevant to prognosis. Combining FISH with IHC, MYCN protein stability could be identified.

Published in BMC Pediatrics

ISSN: 1471-2431 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Pediatrics
Website: https://bmcpediatr.biomedcentral.com

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Abstract

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