Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

Hanjun Zhao; Kelvin K. W. To; Hin Chu; Qiulu Ding; Xiaoyu Zhao; Cun Li; Huiping Shuai; Shuofeng Yuan; Jie Zhou; Kin-Hang Kok; Shibo Jiang; Kwok-Yung Yuen

doi:10.1038/s41467-018-04792-7

Nature Communications (Jun 2018)

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

Hanjun Zhao,
Kelvin K. W. To,
Hin Chu,
Qiulu Ding,
Xiaoyu Zhao,
Cun Li,
Huiping Shuai,
Shuofeng Yuan,
Jie Zhou,
Kin-Hang Kok,
Shibo Jiang,
Kwok-Yung Yuen

Affiliations

Hanjun Zhao: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Kelvin K. W. To: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Hin Chu: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Qiulu Ding: Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Xiaoyu Zhao: Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Cun Li: Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Huiping Shuai: Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Shuofeng Yuan: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Jie Zhou: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Kin-Hang Kok: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Shibo Jiang: Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University
Kwok-Yung Yuen: State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong

DOI: https://doi.org/10.1038/s41467-018-04792-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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A limited number of therapeutics is available to treat influenza A virus (IAV) infections. Here, the authors show that defective interfering genes, delivered with a dual-functional peptide that enables intracellular accumulation and prevents endosomal acidification, inhibit IAV replication in vitro and in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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