Survival rate of endometrial cancer patients at Phramongkutklao Hospital

Abstract

Objective:To determine the five-year overall survival rate of patients with endometrial cancer after complete treatment at Phramongkutklao Hospital.Materials and Method: This was a retrospective descriptive study. A total of 54 patients were enrolled, each with a histologically confirmed diagnosis of endometrial cancer and had received complete treatment from January 1, 2009 to December 31, 2010 at Phramongkutklao hospital. Overall survival was estimated according to the Kaplan-Meier method and a univariate analysis employed the Log-rank test to compare between groups.Main outcome measure: The five-year overall survival rate of patients with endometrial cancer.Results:The mean age of the 54 patients was 60 ± 10.6 years. All patients presented with the symptom of abnormal uterine bleeding. The majority of patients in this study had early stage disease (66.7%) and, histopathology cell types which were endometrioid carcinoma (90.6%). The majority of adjuvant therapies in advanced stage was chemotherapy plus radiotherapy (27.7%), and for early stage was radiotherapy alone (33.4%). The five-year overall survival rate of endometrial cancer was 80.1%, however this depended on the stage of cancer. In the early stage (FIGO stage I-II) it was 91.6% while in the advanced stage (FIGO stage III-IV) it was 50%. The statistically significant variables affecting overall survival included stage, tumor grade, cervical invasion, lymph nodes metastasis, positive peritoneal cytology and post operative residual tumor more than 2 cm.Conclusion: The five-year overall survival rate of endometrial cancer was 80.1%. The FIGO stage and tumor grade were correlated with the overall survival rate of patients with endometrial cancer.

Keywords

• survival rate
• endometrial cancer
• The 2009 FIGO staging