Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G

Abstract

APOBEC3G inhibits HIV-1 viral replication via catalytic and non-catalytic processes. Here the authors show that APOBEC3G binds single-stranded DNA as an active deaminase monomer, subsequently forming catalytic-inactive dimers that block reverse transcriptase-mediated DNA synthesis.