The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Takeshi Nakatani; Kohei Tsujimoto; JeongHoon Park; Tatsunori Jo; Tetsuya Kimura; Yoshitomo Hayama; Hachiro Konaka; Takayoshi Morita; Yasuhiro Kato; Masayuki Nishide; Shyohei Koyama; Shigeyuki Nada; Masato Okada; Hyota Takamatsu; Atsushi Kumanogoh

doi:10.1038/s41467-021-23654-3

Nature Communications (Jun 2021)

The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Takeshi Nakatani,
Kohei Tsujimoto,
JeongHoon Park,
Tatsunori Jo,
Tetsuya Kimura,
Yoshitomo Hayama,
Hachiro Konaka,
Takayoshi Morita,
Yasuhiro Kato,
Masayuki Nishide,
Shyohei Koyama,
Shigeyuki Nada,
Masato Okada,
Hyota Takamatsu,
Atsushi Kumanogoh

Affiliations

Takeshi Nakatani: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Kohei Tsujimoto: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
JeongHoon Park: The Japan Science and Technology – Core Research for Evolutional Science and Technology (JST–CREST), Osaka University
Tatsunori Jo: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Tetsuya Kimura: Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University
Yoshitomo Hayama: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Hachiro Konaka: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Takayoshi Morita: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Yasuhiro Kato: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Masayuki Nishide: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Shyohei Koyama: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Shigeyuki Nada: Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University
Masato Okada: Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University
Hyota Takamatsu: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University
Atsushi Kumanogoh: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University

DOI: https://doi.org/10.1038/s41467-021-23654-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes with the interaction between MPRIP and a subunit of myosin light chain phosphatase (MLCP).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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