Discovery of Anti-Inflammatory Triterpenoid Glucosides from the <i>Heritiera littoralis</i> Dryand
Xiaoqin Liang,
Peng Niu,
Jun Li,
Xinlan Guan,
Yanjun Zhang,
Jian Li
Affiliations
Xiaoqin Liang
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, China
Peng Niu
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, China
Jun Li
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemical & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
Xinlan Guan
Peoples’ Hospital of Pubei, Qinzhou 535300, China
Yanjun Zhang
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, China
Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC50 value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.
