Sorafenib, a systemic therapy for hepatocellular carcinoma

Abstract

Hepatocellular carcinoma is a lethal disease that requires a multidisciplinary approach and management. Surgical therapy offers long-term survival; however, few patients are candidates. There has been no accepted systemic therapy for this disease until recently. This article briefly discusses the role of RAS/RAF/MEK/ ERK signaling pathway in the pathogenesis of the disease and the promising role of sorafenib for advanced disease.

Keywords

• Liver cancer
• hepatocellular carcinoma
• HCV
• HBV
• sorafenib