Assessment of pro- and anti-inflammatory cytokine levels in two-phase surgical treatment of patients with advanced proliferative diabetic retinopathy

Abstract

The purpose is to estimate the content of pro- and anti-inflammatory cytokines (IL-1 , IL-8, IL-10, MCP-1, ICAM-1, VEGF) in the tear liquid of patients with advanced proliferative diabetic retinopathy (PDR) and complicated primary cataract after phacoemulsification and IOL implantation performed simultaneously with vitreoretinal surgery vs. vitreoretinal surgery alone. Material and methods. 34 patients with PDR and complicated primary cataract were divided into two groups. Group 1 received a two-phase surgical procedure: (a) vitreoretinal surgery (VRS) with silicone oil tamponade followed by (b) phacoemulsification surgery, IOL implantation and silicone oil removal. Group 2 was subjected to (a) phacoemulsification simultaneously with vitreoretinal surgery and silicone oil tamponade and (b) silicone oil removal from the vitreous cavity. Both groups had their tear liquid samples examined before the surgery and on the 2nd day after the 1stphase. Results. Group 2 revealed a 2 to 2.5 times higher concentration of IL-8, MCP-1 and ICAM-1 as compared to Group 1. Conclusion. Increased concentrations of IL-8, MCP-1, and ICAM-1 in the tear after phacoemulsification surgery and IOL implantation coupled with vitreoretinal surgery as compared to vitreoretinal surgery alone requires additional research of the role played by the inflammatory component in the pathogenesis of postsurgical complications in advanced PDR patients.

Keywords

• цитокины
• пролиферативная диабетическая ретинопатия
• витреоретинальная хирургия
• факоэмульсификация катаракты