Revista da Sociedade Brasileira de Medicina Tropical ()

Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro

  • Rejane Maria Tommasini Grotto,
  • Natália Mirele Cantão,
  • Juliana Lara Padovani,
  • Lenice do Rosário de Souza,
  • Giovanni Faria Silva,
  • Adriana Camargo Ferrasi,
  • Maria Inês de Moura Campos Pardini

DOI
https://doi.org/10.1590/0037-8682-0105-2016
Journal volume & issue
Vol. 49, no. 4
pp. 491 – 493

Abstract

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Abstract: INTRODUCTION: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. METHODS: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. RESULTS: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. CONCLUSIONS: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.

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