Reactive oxygen species-responsive hydrogel loaded with melatonin as a minimally invasive treatment for myocardial I/R injury
Hechen Shen,
Xu Bao,
Bingcai Qi,
Xiaoyu Liang,
Yun Chang,
Xiaomin Hu,
Wenqing Gao,
Di Sun
Affiliations
Hechen Shen
The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, P.R. China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Artificial Cell Engineering Technology Research Center, Tianjin 300170, P.R. China
Xu Bao
The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, P.R. China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Artificial Cell Engineering Technology Research Center, Tianjin 300170, P.R. China
Bingcai Qi
Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China
Xiaoyu Liang
Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Artificial Cell Engineering Technology Research Center, Tianjin 300170, P.R. China
Yun Chang
Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Artificial Cell Engineering Technology Research Center, Tianjin 300170, P.R. China
Xiaomin Hu
Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Artificial Cell Engineering Technology Research Center, Tianjin 300170, P.R. China; School of Medicine, Nankai University, Tianjin 300170, P.R. China; Nankai University Affiliated Third Center Hospital, Nankai University, Tianjin 300170, P.R. China
Wenqing Gao
Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P.R. China; Tianjin ECMO Treatment and Training Base, Tianjin 300170, P.R. China; Artificial Cell Engineering Technology Research Center, Tianjin 300170, P.R. China; School of Medicine, Nankai University, Tianjin 300170, P.R. China; Nankai University Affiliated Third Center Hospital, Nankai University, Tianjin 300170, P.R. China; Corresponding author
Di Sun
Key Laboratory of Photochemical Conversion and Optoelectronic Material, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China; Corresponding author
Summary: Myocardial infarction (MI) poses a severe threat to human life, and timely reperfusion of ischemic myocardium stands as the most effective treatment approach. However, myocardial ischemia-reperfusion (I/R) could lead to the excessive generation of reactive oxygen species (ROS), worsening myocardial injury. In this investigation, an ROS-responsive injectable hydrogel encapsulating melatonin (MLT) was synthesized. This hydrogel could provide a controlled release of MLT, markedly enhancing its antioxidant, anti-inflammatory, anti-apoptotic, and autophagy-modulating effects, thereby significantly mitigating myocardial ischemia-reperfusion injury (MIRI). Moreover, this study proposes an injection method of ultrasound delivery, which offers significant advantages to MI patients without the necessity of thoracotomy. In conclusion, This ROS-responsive hydrogel loaded with MLT established the basis for minimally invasive treatment of myocardial I/R injury, which has considerable potential for the treatment of MIRI.
