Frontiers in Bioengineering and Biotechnology (Feb 2022)

Preparation and Characterization of Vancomycin Hydrochloride-Loaded Mesoporous Silica Composite Hydrogels

  • Ming Sun,
  • Ming Sun,
  • Lidi Cheng,
  • Lidi Cheng,
  • Zexian Xu,
  • Zexian Xu,
  • Liqiang Chen,
  • Liqiang Chen,
  • Liqiang Chen,
  • Yanshan Liu,
  • Yanshan Liu,
  • Yanshan Liu,
  • Yaoxiang Xu,
  • Yaoxiang Xu,
  • Dongyang Zhou,
  • Dongyang Zhou,
  • Xiuxiu Zhang,
  • Xiuxiu Zhang,
  • Qihui Zhou,
  • Qihui Zhou,
  • Qihui Zhou,
  • Jian Sun,
  • Jian Sun,
  • Jian Sun,
  • Jian Sun

DOI
https://doi.org/10.3389/fbioe.2022.826971
Journal volume & issue
Vol. 10

Abstract

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This study aims to explore the feasibility of the novel temperature-sensitive hydrogel-based dual sustained-release system (Van/SBA-15/CS-GP-SA) in the repair and treatment of infectious jaw defects. Van/SBA-15 was prepared using the mesoporous silica (SBA-15) as a carrier for vancomycin hydrochloride (Van), and Van/SBA-15 was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Brunauer–Emmett–Teller (BET), and Barrett–Joyner–Halenda (BJH). The characterization results confirm that Van is loaded in SBA-15 successfully. Van/SBA-15/CS-GP-SA is constructed by encapsulating Van/SBA-15 in chitosan–sodium glycerophosphate–sodium alginate hydrogel (CS-GP-SA). The microstructures, sustained-release ability, biocompatibility, and antibacterial properties of Van/SBA-15/CS-GP-SA were systematically studied. Van/SBA-15/CS-GP-SA is found to have promising sustained-release ability, outstanding biocompatibility, and excellent antibacterial properties. This study provides new ideas for the management of infectious jaw defects.

Keywords