Biokinetic datasets of PEI F25-LMW complexed and non-complexed 32P-siRNA within different lung compartments
Jens Lipka,
Manuela Semmler-Behnke,
Alexander Wenk,
Jana Burkhardt,
Achim Aigner,
Wolfgang Kreyling
Affiliations
Jens Lipka
Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München – German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany; Philipps-University of Marburg Department of Pharmaceutics and Biopharmacy, Ketzerbach 63, 35037 Marburg, Germany
Manuela Semmler-Behnke
Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München – German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany
Alexander Wenk
Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München – German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany
Jana Burkhardt
Fraunhofer Institute for Cell Therapy and Immunology (IZI) Leipzig, Perlickstraße 1, 04103 Leipzig, Germany
Achim Aigner
Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology University of Leipzig, Haertelstrasse 16–18, 04107 Leipzig, Germany
Wolfgang Kreyling
Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München – German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany; Corresponding author at: Institute of Epidemiology 2Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1,85764 Neuherberg, Germany. Tel.: +49 89 3187 2309; fax: +49 89 3187 3397.
Biokinetics data of lung-administered PEI F25-LMW/siRNA polyplexes within different lung compartments are presented. Thereby, at three different timepoints (1 h, 3 h, 8 h), the data was determined by calculations to the 32P-radioactivity in the whole mouse body. Additionally, data was optimized to the available PEI F25-LMW/siRNA polyplexes in the target organ and therefore normalized to the sum of all lung compartments. Methods, other biokinetics data and the discussion of the results are published in “Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice” (Lipka et al., 2016 [1]). Keywords: Biokinetic data, Lung, PEI
