Genome wide association analysis in a mouse advanced intercross line

Natalia M. Gonzales; Jungkyun Seo; Ana I. Hernandez Cordero; Celine L. St. Pierre; Jennifer S. Gregory; Margaret G. Distler; Mark Abney; Stefan Canzar; Arimantas Lionikas; Abraham A. Palmer

doi:10.1038/s41467-018-07642-8

Nature Communications (Dec 2018)

Genome wide association analysis in a mouse advanced intercross line

Natalia M. Gonzales,
Jungkyun Seo,
Ana I. Hernandez Cordero,
Celine L. St. Pierre,
Jennifer S. Gregory,
Margaret G. Distler,
Mark Abney,
Stefan Canzar,
Arimantas Lionikas,
Abraham A. Palmer

Affiliations

Natalia M. Gonzales: Department of Human Genetics, University of Chicago
Jungkyun Seo: Center for Genomic & Computational Biology, Duke University
Ana I. Hernandez Cordero: School of Medicine, Medical Sciences and Nutrition, College of Life Sciences and Medicine, University of Aberdeen
Celine L. St. Pierre: Department of Genetics, Washington University School of Medicine
Jennifer S. Gregory: School of Medicine, Medical Sciences and Nutrition, College of Life Sciences and Medicine, University of Aberdeen
Margaret G. Distler: Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles
Mark Abney: Department of Human Genetics, University of Chicago
Stefan Canzar: Gene Center, Ludwig-Maximilians-Universität München
Arimantas Lionikas: School of Medicine, Medical Sciences and Nutrition, College of Life Sciences and Medicine, University of Aberdeen
Abraham A. Palmer: Department of Psychiatry, University of California San Diego

DOI: https://doi.org/10.1038/s41467-018-07642-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis. Here, the authors analyze 1,063 LG x SM AIL mice to identify significant associations for 50 traits relevant to human health and disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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