Medical College of Yan’an University, Yan’an University, Yan’an 716000, China
Lingbo Sun
Medical College of Yan’an University, Yan’an University, Yan’an 716000, China
Changda Lei
Department of Gastroenterology, Ninth Hospital of Xi‘an, Xi’an 710054, China
Wenyan Li
Medical College of Yan’an University, Yan’an University, Yan’an 716000, China
Jiaqi Han
Medical College of Yan’an University, Yan’an University, Yan’an 716000, China
Jing Zhang
Medical College of Yan’an University, Yan’an University, Yan’an 716000, China
Yuecheng Zhang
Key Laboratory of Analytical Technology and Detection of Yan’an, College of Chemistry and Chemical Engineering, Yan’an University, Yan’an 716000, China
Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed.
