Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013–2014)

Xin Xie; Congying Lu; Min Wu; Jiayu Liang; Yuting Ying; Kailiang Liu; Xiuxia Huang; Shaoling Zheng; Xiuben Du; Dandan Liu; Zihao Wen; Guang Hao; Guang Yang; Liping Feng; Chunxia Jing

Environment International (Mar 2020)

Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013–2014)

Xin Xie,
Congying Lu,
Min Wu,
Jiayu Liang,
Yuting Ying,
Kailiang Liu,
Xiuxia Huang,
Shaoling Zheng,
Xiuben Du,
Dandan Liu,
Zihao Wen,
Guang Hao,
Guang Yang,
Liping Feng,
Chunxia Jing

Affiliations

Xin Xie: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Congying Lu: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Min Wu: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Jiayu Liang: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Yuting Ying: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Kailiang Liu: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Xiuxia Huang: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Shaoling Zheng: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Xiuben Du: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Dandan Liu: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Zihao Wen: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China
Guang Hao: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China; Corresponding authors at: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China (G. Hao). Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA (L. Feng).
Guang Yang: Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China; Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, Guangdong, China; Corresponding authors at: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China (G. Hao). Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA (L. Feng).
Liping Feng: Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA; Corresponding authors at: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China (G. Hao). Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA (L. Feng).
Chunxia Jing: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China; Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, Guangdong, China; Corresponding authors at: Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China (G. Hao). Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA (L. Feng).

Journal volume & issue: Vol. 136

Abstract

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Background: There has been increasing interest in the concept that exposure to environmental chemicals may be contributing factors to epidemics of diabetes mellitus (DM). Triclocarban and triclosan (TCs) are synthetic antibacterial chemicals that are widely used in personal care products. Studies have shown that TCs are endocrine disruptors that alter metabolic conditions. However, it remains unclear whether exposure to TCs is a risk factor for impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). Objective: We explored the hypothesis that TCs exposure is associated with an increased risk of IGT and T2DM. Method: To test our hypothesis, we analyzed the U.S. National Health and Nutrition Examination Survey (NHANES) cross-sectional data from 2013 to 2014. IGT and T2DM were diagnosed based on an oral glucose tolerance test (OGTT) and the WHO standards. The levels of urinary TCs were measured using an HPLC-MS/MS method that NHANES investigators developed. The association between urinary TCs status and IGT and T2DM was examined separately in men and women using multivariable logistic regression models adjusted for age, race, BMI, education, ratio of family income to poverty, smoking, exercise and hypertension. Results: Nine hundred US participants (429 men and 471 women) were included in the analysis, of whom 242 (26.89%) were diagnosed with T2DM and 117 (13.00%) had IGT. Among women, there was a significant positive association between triclocarban, but not triclosan exposure and T2DM (OR: 1.79, 95% CI: 1.05, 2.05) after adjusting for potential confounding factors. Among men, no significant association between TCs exposure and IGT or T2DM was observed. Conclusions: Triclocarban exposure may increase the risk of T2DM in the women, although additional studies are needed to confirm the results of this study and to investigate the underlying mechanisms. Keywords: Triclocarban, Triclosan, T2DM, IGT

Published in Environment International

ISSN: 0160-4120 (Print)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environment-international

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