Nature Communications (Feb 2018)

A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia

  • Santosh Kumar Kuncha,
  • Mohd Mazeed,
  • Raghvendra Singh,
  • Bhavita Kattula,
  • Satya Brata Routh,
  • Rajan Sankaranarayanan

DOI
https://doi.org/10.1038/s41467-017-02204-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The number of tRNA isodecoders has expanded significantly during evolution, which has resulted in ambiguity in tRNA selection by synthetases. Here the authors identify and characterize a dedicated proofreading factor that eliminates errors caused by ambiguity in tRNA selection by eukaryotic tRNA synthetases.