Проблемы особо опасных инфекций (Aug 2012)

Phenotypic and Molecular-Genetic Analysis of Genetically Modified Toxigenic <I>Vibrio cholerae</I> El Tor Strain 301, Isolated in 2011 in Russia

  • A. V. Shashkova,
  • D. A. Agafonov,
  • A. V. Cherkasov,
  • S. P. Zadnova,
  • N. I. Smirnova

DOI
https://doi.org/10.21055/0370-1069-2012-4-61-64
Journal volume & issue
Vol. 0, no. 4(114)
pp. 61 – 64

Abstract

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The phenotypic and molecular-genetic analysis of Vibrio cholerae O1 El Tor Inaba strain 301, isolated in 2011 from sea water in recreation zone in Taganrog, demonstrated this isolate to be a genetic variant of El Tor cholera causative agent. Its genome was shown to carry a hybrid prophage, containing gene ctxB of classical type and gene rstR of El Tor type, as well as altered pathogenicity island VPI-1 and pandemicity island VSP-II. This strain produced much more cholera toxin (0,12 mcg/ml) than typical strains of this causative agent.

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