Role of Ozone in Surgical Complication of Diabetic Patients

Abstract

Background: Diabetes Mellitus (DM) is a metabolic disorder, caused by impaired carbohydrate metabolism makes many changes in the blood vessels affecting the response of endothelium and the smooth muscles. Polyol pathway activation, protein non-enzymatic glycosylation and increased ROSs(reactive oxidative species) play an important role in the complications of diabetes.Ozone activates glucose metabolism that results in increasing content of 2,3diphosphoglycerate in erythrocytes which provides better oxygen supply into the tissues. Patients with diabetes mellitus have the so called glycosylated hemoglobin forming very strong bonds with oxygen, thus, inducing hypoxia and determining the severity of the disease. That is why hypoxia control with the help of ozone therapy is of the key importance in the course of treatment. Conclusion: Ozone therapy appears to be an effective method for DM treatment. The reason is inozone mechanisms when it can perform a number of processes, which provide its positive effect.

Keywords

• ozone; diabetes mellitus; surgical complications