New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i>
Wen-bing Ding,
Rui-yuan Zhao,
Guan-hua Li,
Bing-lei Liu,
Hua-liang He,
Lin Qiu,
Jin Xue,
You-zhi Li
Affiliations
Wen-bing Ding
Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China
Rui-yuan Zhao
Hunnan Cotton Science Institute, Changde 415100, China
Guan-hua Li
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
Bing-lei Liu
Hunnan Cotton Science Institute, Changde 415100, China
Hua-liang He
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
Lin Qiu
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
Jin Xue
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
You-zhi Li
Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China
Five new cyclic diarylheptanoids (platycary A–E, compounds 1–5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1–5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ.
