Risk Management and Healthcare Policy (Oct 2020)

Meteorological Condition and Air Pollution Exposure Associated with Vitamin D Deficiency: A Cross-Sectional Population-Based Study in China

  • He H,
  • Zeng Y,
  • Wang X,
  • Yang L,
  • Zhang M,
  • An Z

Journal volume & issue
Vol. Volume 13
pp. 2317 – 2324

Abstract

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He He,1,* Yuping Zeng,1,* Xia Wang,1 Lidan Yang,1 Mei Zhang,1 Zhenmei An2 1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mei Zhang Department of Laboratory MedicineWest China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu, People’s Republic of ChinaEmail [email protected]: The aim of this study was to investigate the status of Vitamin D deficiency and the effect of environmental factors on Vitamin D levels so as to provide theoretical support for public health promotion in this region.Methods: A total of 22,387 subjects who underwent a physical examination at the center in the West China Hospital, Sichuan University, between April, 2018 and May, 2020 were enrolled in this study. Their data on gender, age, inspection date, serum 25 hydroxyvitamin D (25-(OH) D), parathyroid hormone (PTH), and total calcium were retrospectively reviewed. Next, the percentage of Vitamin D status was compared in different sex and age groups, and the fluctuation of Vitamin D level was described in relation to the change of environment. Finally, the univariable and multivariable linear regression analyses were performed to explore the risk and protective factors of Vitamin D deficiency.Results: The proportion of Vitamin D deficiency in this area was 42.17%, and it was significantly higher among women and young people. The fluctuation trend of 25-(OH) D levels are consistent with temperature and solar radiation, and opposite to air quality, in the whole year. There was a positive relationship between 25-(OH) D levels with temperature and solar radiation; however, parathyroid hormone, female and AQI were negatively correlated with Vitamin D levels.Conclusion: Vitamin D deficiency is common in subtropic areas, such as Sichuan Basin, which is related to solar radiation and air pollution.Keywords: Vitamin D deficiency, 25 hydroxyvitamin D, environmental factors, air quality index

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