Nature Communications (Nov 2019)

A fln-2 mutation affects lethal pathology and lifespan in C. elegans

  • Yuan Zhao,
  • Hongyuan Wang,
  • Richard J. Poole,
  • David Gems

DOI
https://doi.org/10.1038/s41467-019-13062-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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C. elegans is a commonly used model organism in the study of ageing, and differences in genetic background can result in varying strain longevity. Here the authors demonstrate that a background mutation in fln-2 affects life-limiting pharyngeal infection and that in the mutant background the beneficial effect of sir-2.1 over-expression is suppressed.