RISK FACTORS AND CYTOMORPHOLOGICAL CHARACTERISTICS OF THE CHORION IN THE GENESIS OF SPONTANEOUS ABORTION IN FIRST TRIMESTER

Abstract

Cytomorphological features of the chorion and risk factors for spontaneous abortion in the first trimester are studied. A total of 98 pregnant women were divided into 2 groups: the 1st (main) group - 38 pregnant women with spontaneous abortion in 1 trimester (38.78%), 2nd (control) group - 60 pregnant women with induced abortion 1 trimester (61,22%). One of the major risk factors for spontaneous abortion was a chronic persistent viral infection: expression of the investigated agents (Herpes simplex virus types 1 and 2, Cytomegalovirus, a virus Epstein-Barr), reached 84.2% and 88.33%, which, in the absence of inflammatory manifestations in the tissues of the chorion, reflected a significant infection of women and, probably, their predisposition to miscarriage. The results of serological investigations of studied agents not always indicated the infection of chorionic structures with these pathogens. Chronic viral infections had persistent subclinical character. Therefore the great importance in predicting of their effects on pregnancy had evaluation of the percentage of leukocytes, leukocyte index of intoxication and platelets. The most significant anamnestic risk factor for spontaneous abortion was spontaneous termination of previous pregnancies. Morphological changes in the structures of the chorion in spontaneous abortion in first trimester were heterogeneous, but most were caused by infectious disorders caused by pathogens TORCH-complex (70%). In determining the localization of pathogens chorionic tissues revealed expression of the most frequently studied pathogens in the trophoblastic epithelium and stromal cells of the villi, indicating on penetration of pathogens in the placenta.

Keywords

• spontaneous abortion
• risk factors
• chorion
• viral infection