Communications Biology (Oct 2022)

An anti-influenza combined therapy assessed by single cell RNA-sequencing

  • Chiara Medaglia,
  • Ilya Kolpakov,
  • Arnaud Charles-Antoine Zwygart,
  • Yong Zhu,
  • Samuel Constant,
  • Song Huang,
  • Valeria Cagno,
  • Emmanouil T. Dermitzakis,
  • Francesco Stellacci,
  • Ioannis Xenarios,
  • Caroline Tapparel

DOI
https://doi.org/10.1038/s42003-022-04013-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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When combined with interferon lambda, virucidal sialylated cyclodextrins inhibit the replication of a clinical H1N1 influenza strain in ex vivo human airway epithelia more efficiently than when delivered alone.