Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties – Synthesis and biological activity

Abstract

2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of a set of 1,2,3-triazole, thiourea, and ebselen derivatives. Cytotoxicity and antiviral activity studies revealed the most promising potency for selected thioureas.

Keywords

• Antiviral activity
• 2-azabicycloalkane
• Cytotoxicity
• Ebselen
• Thiourea
• 1,2,3-triazole