Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

Benedict Tanudjojo; Samiha S. Shaikh; Alexis Fenyi; Luc Bousset; Devika Agarwal; Jade Marsh; Christos Zois; Sabrina Heman-Ackah; Roman Fischer; David Sims; Ronald Melki; George K. Tofaris

doi:10.1038/s41467-021-23682-z

Nature Communications (Jun 2021)

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

Benedict Tanudjojo,
Samiha S. Shaikh,
Alexis Fenyi,
Luc Bousset,
Devika Agarwal,
Jade Marsh,
Christos Zois,
Sabrina Heman-Ackah,
Roman Fischer,
David Sims,
Ronald Melki,
George K. Tofaris

Affiliations

Benedict Tanudjojo: Nuffield Department of Clinical Neurosciences, University of Oxford
Samiha S. Shaikh: Nuffield Department of Clinical Neurosciences, University of Oxford
Alexis Fenyi: CEA, Institut François Jacob (MIRCen) and CNRS, Laboratory of Neurodegenerative Diseases
Luc Bousset: CEA, Institut François Jacob (MIRCen) and CNRS, Laboratory of Neurodegenerative Diseases
Devika Agarwal: MRC Centre for Computational Biology, University of Oxford
Jade Marsh: Nuffield Department of Clinical Neurosciences, University of Oxford
Christos Zois: MRC Weatherall Institute of Molecular Medicine, University of Oxford
Sabrina Heman-Ackah: Department of Neurosurgery, University of Pennsylvania
Roman Fischer: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
David Sims: MRC Centre for Computational Biology, University of Oxford
Ronald Melki: CEA, Institut François Jacob (MIRCen) and CNRS, Laboratory of Neurodegenerative Diseases
George K. Tofaris: Nuffield Department of Clinical Neurosciences, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-23682-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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α-Synuclein aggregation contributes to Parkinson’s disease and related disorders. Here the authors investigate patterns of α-synuclein aggregation in human dopaminergic neurons in response to fibrils derived from individuals with Parkinson’s disease or multiple system atrophy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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